Mini ReviewIntracellular Vomit Signals and Cascades Downstream of Emetic Receptors: Evidence from the Least Shrew (Cryptotis parva) Model of Vomiting
Nausea and vomiting are often considered as stressful symptoms of many diseases and drugs.
Mini ReviewIntracellular Vomit Signals and Cascades Downstream of Emetic Receptors: Evidence from the Least Shrew (Cryptotis parva) Model of Vomiting
Nausea and vomiting are often considered as stressful symptoms of many diseases and drugs.
Case ReportCytomegalovirus Infection and Multiple Venous Thrombosis: A Rare Complication of a Common Infection
Background: Cytomegalovirus (CMV) is a common cause of viral infection. In immunocompetent patients, CMV infection is usually mild or asymptomatic and does not require any treatment.
Research ArticleSuccessful Treatment of Living Donor Liver Transplantation Patients with Recurrent Hepatitis C Virus by Interferon-Free Therapy with Direct-Acting Antivirals
Re-infection of Hepatitis C Virus (HCV) to the transplanted liver happens in virtually all cases and is refractory to treatment.
Research ArticleDepression and Anxiety among Females with Breast Cancer in Sohag University: Results of an Interview Study
Background: Limited research on psychiatric disorders prevalence among Upper Egyptian women treated for breast cancer.
Short CommunicationPhysician Assistants as Associates & Mentors
This article is meant to persuade physicians as well as physician assistants that the experience, knowledge and methodologies forged by the maturation of careers now well into decade’s long expertise deserve more recognition than they are getting today.
Case ReportSkeletal Sarcoidosis Mimicking Metastatic Ovarian Cancer – A Case with FDG-PET/CT
Sarcoidosis during or after chemotherapy for cancer is not common; however, when it occurs, it may mimic metastases.
Research ArticleChiari Malformation Type 1: Clinical Features, Diagnosis and Treatment- An Italian Case Series
Chiari type 1 Malformation (CM 1) is characterized by caudal displacement of the cerebellar tonsils through the foramen magnum with obstruction of cerebrospinal fluid (CSF) outflow.
Research ArticleDynamic Core Intervention for a Child with Cerebral Palsy
Purpose: To describe and assess the Dynamic Core for Kids (DC4K) model of intervention that promotes central stability as an alternative to conventional trunk strengthening programs for a child with Cerebral Palsy.
EditorialThe Emerging Field of Neuro-Optometry Provides a Synergistic Effect with Ophthalmology
In addition to saving and maintaining eye health, ophthalmologists perform surgery and prescribe glasses to help patients use central eyesight at a conscious level to identify 20/20 letters (non-moving targets).
EditorialEvaluating the Relation of Refractive Surgery and Glaucoma
Laser-assisted refractive corrections constitute a large part of the ophthalmic surgeries that take place every year.
Case ReportLow Grade Fibromyxoid Sarcoma of the Axillary Fossa and Breast Cancer – A Case Report
Low grade fibromyxoid sarcoma (LGFMS) is a rare tumor, they are usually located in the lower limbs or any other location is possible.
EditorialUrological Complications in Obstetrics and Gynaecology
Urological injuries have been inescapably associated with gynaecological and obstetrical surgeries, owing to anatomic proximities of urogenital organs.
Research ArticleAnti-Inflammatory Mediated Wound Healing Activity of Mefenamic Acid with Honey in Wistar Rats
Inflammation is defined as a sequence of events that occurs in response to noxious stimuli, infection or trauma.
Short CommunicationRadiation Therapy in the Treatment of Resectable Locally Advanced Gastric Adenocarcinoma: Present and Future
In the United States, patients with Gastric Adenocarcinoma (GA) confined to the stomach have a 5 year overall survival (OS) rate of approximately 67% which is reduced to 31% and 5% with nodal or distant metastatic spread, respectively .
PerspectiveRadiofrequency Ablation for Treatment of Cervicogenic Headache: Where do we stand?
Cervicogenic headache (CH) is a syndrome characterized by unilateral head pain caused by a disorder of the cervical spine and its component bone, disc, and/or soft tissue elements, usually but not invariably accompanied by the neck pain .
Research ArticleChallenges in Nursing: The Psychological Needs of Rural Area Nurses in Mpumalanga, South Africa
Primary health care nurses play an important role as the first and often the only contact providing primary health care services in rural disadvantaged communities.
Research ArticleThe Use of Intravenous Baclofen as Therapy for the γ-hydroxybutyric Acid Withdrawal Syndrome
Introduction: In this case series with three patients, we introduced baclofen, a γ-aminobutyric acid type B(GABA-B) receptor agonist, for treatment of the γ-hydroxybutyric acid (GHB) withdrawal syndrome.
EditorialIs the Fascination and Publication Flood of ICG Fluorescence in General Surgery Justified?
Indocyanin green (ICG) evolved during World War II as a dye for photography and was first introduced in medicine at the Mayo clinic in 1957 .
Short CommunicationThe present study investigated the response property of neurons in ventralateral orbital cortex (VLO) to peripheral mechanical noxious stimuli and nucleus submedius (Sm) injection of glutamate.
Case ReportOsteonecrosis of the Femoral Head in an HIV-Infected Patient on a Protease Inhibitor-Sparing Antiretroviral Combination
Physicians who care for HIV-infected patients are being challenged to deal with osteonecrosis as an emerging complication.
Case SeriesComparison between Four Types of Single-Dose Hyaluronic Acid Injection in Patients with Knee Osteoarthritis: A Randomized Control Trial
Aim: Evaluating and comparing 4 types of hyaluronic acid used as intra-articular injection for knee osteoarthritis in view of their clinical outcome and cost.
Case ReportHair Cortisol as a Biomarker of Stress before and after Subarachnoid Hemorrhage: A Case Report
The aim was to study stress in the acute and post-acute phase in patients with severe traumatic brain injury (TBI) or non-traumatic subarachnoid hemorrhage (SAH) who were treated at the neurointensive care unit (NICU).
EditorialKounis Syndrome due to Drugs: Increasing Awareness of a Still under Diagnosed Condition
It has been more than 25 years since Kounis and Zavras first reported “the concept of allergic angina” to describe the concomitant appearance of an allergic reaction and an acute coronary syndrome , later defined as “Kounis syndrome” (KS).
Research ArticleTreating Human Hepatocyte-like C3A Cells with Estrogen, Thyroid Hormone, and Insulin Reduced the Ability of PCSK9 to Form Complexes with the LDL Receptor
Atherosclerotic-related diseases resulting from hypercholesterolemia kills more people than any other cause of death worldwide. Proprotein convertase subtilisin/kexin 9 (PCSK9) and the lowdensity lipoprotein (LDL) receptor are two genes that when mutated lead to hypercholesterolemia.
Research ArticleSolar Flux Exhibits a Negative Correlation with Suicide Rate
Aims & Methods: We re-examined the relationship between the sun’s activity and suicide rates. Monthly data from Japan, covering the period from 1976 to 1994, were examined for this purpose.
Research ArticleCorrelation of Western Ontario and Mcmaster Universities Osteoarthritis (WOMAC) and Short Form 36(SF36) Questionnaires in Patients with Knee Osteoarthritis
Background: The aim of the present study was evaluate the correlation between condition-specific and generic health status questionnaires for measuring health-related quality of life in patients with osteoarthritis (OA) of the knee.
EditorialPerspectives and Limitations of Rheumatoid Arthritis Research
Rheumatoid arthritis (RA) is a common, systemic, chronic inflammatory autoimmune disease that affects about 1% of the world population .
Short CommunicationProteins Interacting with PCSK9: A Potential for Personalized Medicine
Hypercholesterolemia is still a major issue in the United States with 73.5 million adults suffering from this illness (https://www.cdc.gov/cholesterol/facts.htm; accessed: May 9, 2017).
EditorialA New Potential of a Sleeping Pill
Orexin was identified as a peptide expressed in specific neurons of the lateral hypothalamic area which is stimulated by falls in circulating glucose but inhibited by feeding-related signals from the visceral organs .
Short CommunicationAfrican American Patients Derive Significant Benefit from the Dual DAA Therapy: A Real World Study in an Urban Medical Center
African Americans (AA) in the US are twice as likely to be infected with HCV compared to the non-Hispanic-white US population (Caucasian; Cau) (3% vs. 1.5%), more likely to be genotype 1, more likely to develop HCC and in addition, have a lower response rate to approved IFN based therapies [1-6].
EditorialReturning to a Pre-Flexner Milieu: Clinician Non-Compliance with Treatment Protocols
“Medical education is not just a program for building knowledge and skills in its recipients… it is also an experience which creates attitudes and expectations.”
Research ArticleLaparoscopic Partial Nephrectomy without Using Floseal or Surgicel Bolster: A Case Series with One and Five Year Outcomes
Introduction: Laparoscopic partial nephrectomy is a minimally invasive treatment option for management of renal masses that allows preservation of sufficient renal parenchyma after complete extirpation of the lesion.
Research ArticleFactors Associated with Female Genital Mutilation among Women of Reproductive Age in Gewane Woreda, Afar National Regional State, Ethiopia
Introduction: Female genital mutilation/cutting is a deeply rooted harmful practice and still highly prevalent in many countries.
Research ArticleOral Cavity as a Source of Atypical Infective Pathogens in Chronic Kidney Disease Patients
Objectives: To investigate the prevalence of pathogens in mouth samples of immunosuppressed patients with Chronic Kidney Disease (CKD).
Research ArticleGene Expression Profiles and Gene Interaction Networks Observed in Peripheral Lymphomononuclear Cell Populations of Recently Diagnosed Type 1 Diabetes Mellitus Patients: Differential Role of HLA Susceptibility Alleles
Type 1 diabetes mellitus (T1DM) is caused by selective destruction of pancreatic β cells, primarily mediated by CD4+T, CD8+T and CD14+ cells.
Research ArticleLaparoscopic Reconstruction for Obstructive Megaureter in Children: A Case Series with Intermediate and Long Term Follow-Up Outcomes
Objective: To narrate our technique of laparoscopic reconstruction for obstructive megaureters in children and report the intermediate and long term outcome.
Case ReportInfluence of Control Data on Diffusion Tensor Imaging in Cervical Spondylotic Myelopathy
Purpose: The aim of this study is to use receiver operating characteristic (ROC) analysis to evaluate the influence of the varying intervertebral disc levels chosen as control groups on the comparative analysis of diffusion tensor imaging (DTI) in patients with cervical spondylotic myelopathy (CSM).
Research ArticleWorsening Back Pain after Bariatric Surgery: The Impact of Acute Weight Loss on the Spine
Background: Obesity increases the risk of low back pain among overweight patients, while weight reduction should result in improving their symptoms.
Research ArticleOccult Spinal Dysraphism: Utility of Cutaneous Lesions as a Screening Tool for Early Diagnosis in a Series of 31 Cases
Background: Occult spinal dysraphism (OSD) is a serious and progressive pathology whose prognosis depends on the type of malformation, and how early it is detected and managed.
Surgical TechniqueSFS Repair and Prolong Dermal Support to Minimise the Stretched Scars after a Skin Excisional Surgery
Scars from the skin cancer surgery of the torso are highly prone to producing distensae striae. This type of scar is cosmetically unsightly.
EditorialRational Treatment of Exudative AMD: The Case for Standardised Practice: "Know-and-Treat"
The treatment of exudative Age-related macular degeneration (AMD) has been revolutionised over the last ten years with the introduction of anti-vascular endothelial growth factor agents (anti-VEGF).
Case ReportSalvage of Bilateral Infected Calcaneal Avulsion Fractures with a Unique Method of Limited Internal Fixation using a Steinman Pin and Wire
Background: Operative management of calcaneal fractures is fraught with complications such as malunions, nonunions, wound problems and infections.
Research ArticleModulation in Pain and EMG Activities with Rigid- and Kinesio-Taping in Athletes with Jumper’s Knee
Purpose: To investigate whether taping could modulate intensity of pain and electromyography activities of vasti muscles in the athletes with jumper’s knee.
Research ArticlePublic Awareness of and Attitudes toward Newborn Screening
Objectives: To understand public awareness of newborn screening and public views on criteria needed for a disorder to be included in universal newborn screening.
Research ArticleMiddle Cerebral Artery Occlusion/Reperfusion Model in Monkeys
This study was designed to develop a reversible middle cerebral artery (MCA) occlusion/reperfusion model in monkeys.
Review ArticleScar Endometriosis: A Review
Extrapelvic endometriosis is a very rare entity and difficult to diagnose majority of which includes incisional scar endometriosis following an obstetric/gynecologic procedure.
Case ReportThree Synchronous Malignancy in a Patient with Psoriasis Treated with Antitumor Necrosis Factor-Alpha: A Case Report and Review of Literature
Anti-tumor necrosis factor-α (anti-TNF) agents are used to treat different autoimmune conditions. Etanercept and Adalimumab are examples of this class of medications used for the treatment of Psoriasis.
Research ArticleBiotoxicity Based on Microtox Fast Testing System and Correlative Material Basis of Shenmai Injection
Microtox assay based on luminous bacterium Vibrio fischeri CS234 was introduced for the first time for quality control of Shenmai injection.
Research ArticleCOL1A1 rs1800012 Polymorphism Associated with Anterior Cruciate Ligament Injuries: A Meta-Analysis
Purpose: To evaluate the relationship between the alpha 1 chain of collagen type I gene (COL1A1) polymorphism and the anterior cruciate ligament (ACL) rupture risk.
Case ReportPostoperative Bleeding after Dental Extraction in Patient with Decompensate Cirrhosis: A Case Report
Patients with cirrhosis are more susceptible to bacteremia and local infection and dental extraction may be required to avoid the spread of local infection.
Case ReportTacrolimus Induced Cerebral Hemorrhagic Posterior Reversible Encephalopathy Syndrome in a Post-Cardiac Transplant Patient
Tacrolimus (FK-506, Prograf) is a potent immunosuppressant agent used in organ and bone marrow transplantation.
Research ArticleA Single Center Experience of Intravenous Corticosteroid Bolus Doses in Graves’ Ophthalmopathy
Exophthalmos makes up a clinical manifestation very frequent in Graves’ disease. European Group on Graves’ Orbitopathy proposes intravenous glucocorticoids to treat severe, moderate-to-severe and active Graves’ orbitopathy as the first line treatment.
Case ReportEvaluating the Effectiveness of Treatment of Methotrexate and Biological Agents in Hand Function and Deformities of Patients with Rheumatoid Arthritis
Objective: The study aims to estimate the types of hand deformities in patients with rheumatoid arthritis (RA) according to the mode of treatment.
EditorialCyclodextrins: Going from Supporting Role to Leading Actor
Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed of 5 or more α-(1,4)-linked glucopyranose subunits among which α-, β-, and γ-cyclodextrin (consisting of six, seven, and eight glucopyranose subunits in a ring, respectively) are the three major types.
Case ReportIndex Pollicization:A Report of 3 Cases and Literature Review
Thumb hypoplasia is one of the common congenital hand deformities. It varies from slight hypoplasia to absent thumb.
Research ArticleRate of Blood Transfusion in Patients Undergoing Bilateral Simultaneous Total Knee Arthroplasty using Patient-Specific Templates and Conventional Techniques: A Comparative Study
Introduction: Blood loss is one of the major concerns for patients undergoing major surgeries such as bilateral simultaneous total knee arthroplasty (TKA).
Research ArticleCandidate Alpha-emitting Radionuclides for Tumor Vascular Disruption Therapy
Microspheres loaded with alpha-emitting radionuclides are an alternative to using 90Y to facilitate tumor vascular disruption.
Case ReportFully Automated Serial Volumetric 3 Dimensional Brain MRI Assesses Grey Matter Volumes and Rate of Progression in a Case of Primary Progressive Multiple Sclerosis
Focal Multiple Sclerosis lesions in white matter (WM) are easily detected with conventional MRI as they have inflammatory properties which generate contrast.
Case ReportDoes Oral Anticoagulant Therapy (OAT) Play a Key Role in Triggering and Maintaining Calcyphilaxis? A Case Report Proposing a New Etiological and Nosological Review
Calcific uremic arteriolopathy (CUA) is a rare but very serious morbid condition often observed during secondary hyperparathyroidism (HPTS).
Case ReportA Pregnant Woman with Hypertension at 36-Week Gestation
Hypertension is the most common medical problem encountered during pregnancy. A case based approach is used to discuss differential diagnosis of hypertension during pregnancy.
Research ArticleNutritional Coaching Process Improve Nutritional Habits and Body Composition without a Diet Prescription Even 36 Weeks after the Last Sessions
One of the most important contemporary health problems is the global prevalence of overweight, but nutritional consultation per se has continuously failed to yield consistent and lasting results.
Review ArticleProposal for a Clinical Approach to Treat Bipolar Disorders Mixed States
It is essential not to forget that the depression is only one phase of a broader bipolar mood disorder, and this has to be the illness to be treated by psychiatrists and, generally, by clinicians managing an appropriate poly therapy with mood-stabilisers and antidepressants.
Case ReportAcute Pulmonary Embolism Induced by Pomalidomide Plus Low-Dose Dexamethasone
Usage of non-ionic contrast agents in patients with multiple myeloma, who have normal creatinine level, is not high risk to develop contrast-induced nephropathy.
Review ArticleSibling Abuse: An Often Unrecognized Family History
Sibling abuse has been recorded in human history since the Old Testament story of Cain and Abel. It is a tragic and often ignored aspect of families.
Review ArticleThe "Inverse" Translational Research: A Proposed New Concept for a Better Clinical Application
Pulmonary medicine is a dynamic discipline. Degenerative and malignant lung disorders have a serious impact on health services all over the world and tremendous efforts are being made for developing new diagnostic technologies and therapeutic options.
Case ReportA Case of Dental Implant Screwdriver Aspiration
A 51-year-old male patient was admitted to our emergency room with an intense chest pain on inspiration and shortness of breath.
Case ReportSuccessful Treatment of Insomnia with Melatonin in a Patient with Malignant Glioma after Radiotherapy-Involving the Pineal Gland
A 29 year old female patient suffering from a biopsy proven anaplastic astrocytoma in the right basal ganglia was treated by conformal radiation therapy with 2 Gy/fraction up to 60 Gy. Near the end of radiotherapy she complained about insomnia.
Research ArticleEnd-of-Life Care for Dementia Patients in the Program of All-inclusive Care for the Elderly (PACE) - A Quality of Care Assessment
Background: The majority of Americans want to die at home, but this occurs <40% of the time. This is particularly challenging for patients with dementia and as our population continues to age, this will become increasingly problematic.
Case ReportCandle in Urinary Bladder- A Rare Entity
Foreign bodies in the urinary bladder are not very common. The causes of foreign body may be multiple. We here present a case of self inserted candle in the urinary bladder of a 56-years-old male that was successfully removed by cystoscopy.
Review ArticleAssessment of Fitness in Cerebral Palsy: Focus in Body Composition and Balance
In Cerebral Palsy (CP) increased stretch reflexes and muscle tone, weakness of involved musculature, and severe limitation of movement reduce the capacity to perform normal movements creating ambulation barriers limiting physical activity.
Research ArticleThe Role of Omega-3 Enriched Diet in the Development and Severity of Retinopathy of Prematurity (ROP)
To evaluate the impact of Omegaven on the development of ROP, we reviewed charts from 170 preterm infants who developed ROP from 01/2010 – 04/2014.
Case ReportIsolated Bladder Neurofibroma: A Case Report and Review of Literature
Neurofibroma, a benign tumor of the nerve sheath, is the result of an abnormal overgrowth of Schwann's cells and fibroblasts. This disorder is often seen in the context of hereditary neurofibromatosis (NF).
Research ArticleLiver Abscess in Diabetic Patients: A Case Series
Liver abscess is defined as a pus heap in a newly formed cavity at the expense of surrounding liver tissue which gets destroyed or repressed. It is a rare and serious infection.
Research ArticleThe Diagnostic Significance of Immunoglobulin Light Chain Gene Expression Signatures by Gene Expression Profiling for B-Cell Lymphoma
Gene expression profiling (GEP) has been shown to have great potential to become a powerful diagnostic tool for lymphoma classification. However, it is not clear whether the expression pattern of immunoglobulin light chain genes defined by GEP can be used as a diagnostic signature to differentiate B-cell lymphoma from B-cell hyperplasia.
Research ArticleSymptoms of Acute Leukemias in the Oral Cavity
Background: The clinical symptoms and mortality of acute leukemias are primarily associated with bone marrow failure as well as other organic infiltrations.
Research ArticleA Novel use of Short Tandem Repeat DNA Analysis to Differentiate Persistent Versus New Ectopic Pregnancy Following Salpingostomy
Ectopic pregnancies treated conservatively by salpingostomy have a 3-20% risk of a persistent ectopic pregnancy. Follow-up serial serum human chorionic gonadotropin (hCG) levels are used to assess adequate treatment.
Review ArticleLaparoscopic Surgery for Anorectal Malformations
The aim of this review article is to review the technique of laparoscopic assisted anorectoplasty (LAARP), its modifications, indications, contraindications and outcomes for anorectal malformations (ARM).
Review ArticleControl of Renin-Angiotensin-Aldosterone System by Oxidative Stress in Renal Diseases - Feedback and Feedforward Mechanism
The Renin-Angiotensin-Aldosterone System (RAAS) plays pivotal role not only in controling blood pressure or hydro-electrolyte balance but also in the pathogenesis of hypertension and renal diseases.
Mini ReviewCholangiocarcinoma and Therapy
Cholangiocarcinoma is a malignant neoplasm originating from biliary epithelial cells. The incidence and mortality of disease are rising in the world. Currently, cholangiocarcinoma is accepted as stem cell disease. There are many risk factors for cholangiocarcinoma.
Research ArticlePlasma Soluble Lectin-Like Oxidized Ldl Receptor 1, A Novel Marker for Atherosclerosis, Is Clinically Associated with Nafld Histological Severity
Aims: Patients with Non-Alcoholic Fatty Liver Disease (NAFLD), especially Steato-Hepatitis (NASH), are at high risk for Cardio Vascular Disease (CVD). Lectin-like oxidized LDL receptor-1 (LOX-1) is associated with CVD, diabetes, and metabolic syndrome.
Research ArticleReappraisal of Bone Scintigraphy and Computed Tomography Data in Patients with Metastatic Prostate Cancer: Initial Appearance of Bone Metastasis between the Staging and Follow-up Periods
Objective: To compare bone scintigraphy (BS) and computed tomography (CT) data between the staging and follow-up periods, clarify the differences in the characteristics of initial skeletal metastasis from prostate cancer, and reappraise the appearance of skeletal metastasis.
Review ArticleReturn to Sport Following a Spring Ligament Reconstruction in a Division I Collegiate Jumper: A Case Report
Introduction: Isolated spring ligament ruptures and reconstructions are rare. To date, there are no published studies documenting the rehabilitation of a spring ligament surgical reconstruction.
Review ArticleClinical Presentation, Diagnosis and Treatment of Choroidal Metastasis from Primary Lung Cancer
Metastasis to the choroid is not uncommon. The most common primary tumor to metastasize to the choroid is lung in men and breast in women. It may present with blurry vision, decreased vision with photopsiae, or pain.